2016 Fiscal Year Final Research Report
Changes in biomarkers after initial periodontal treatment in gingival crevicular fluid from patients with chronic periodontitis presenting with drug-induced gingival overgrowth
| Project/Area Number |
26861809
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Niigata University |
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Principal Investigator |
SHIMIZU TARO 新潟大学, 医歯学総合病院, 医員 (60609121)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 歯肉増殖症 / 歯肉溝浸出液 / マルチプレックスサスペンション |
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| Outline of Final Research Achievements |
The aim of the present study was to simultaneously quantify the levels of 14 biomarkers in gingival crevicular fluid (GCF) samples from sites with both gingival overgrowth (GO) and chronic periodontitis (CP) by multiplex immunoassays.In addition, we examined the relationship between the subgingival microbiota and GCF biomarkers before and after therapy.
we used a multiplex bead immunoassay to detect levels of 12 biomarkers including IL-1β and TGF-β1 in GCF from GO, and we also clarified the presence and quantity of T. denticola from the same sites.
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| Free Research Field |
医歯学
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