Development of the next-generation periodontal regenerative therapy applying TGF-b and nano-DDS technology

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861813
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Periodontology
• Research Institution: Okayama University
• Principal Investigator: Shimoe Masayuki 岡山大学, 医歯薬学総合研究科, 助教 (60580264)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 歯周病 / HMGB1 / 炎症指向性リポソーム / 抗炎症薬

Outline of Final Research Achievements

At first, I clarified that the liposome for targeting inflammatory tissue accumulated at inflammatory periodontal tissue in mouse model of experimental periodontitis. Then, I examined connotation of TGF-β-related protein to the liposome and focused on HMGB1 neutralizing antibody which acted on GDF5, belonged to TGF-β superfamily. HMGB1 was reported the participation to various inflammatory diseases. And HMGB1 neutralizing antibody is expected as new therapeutic drug for those diseases.
As the second step of this study, I manufactured the liposome involving HMGB1 neutralizing antibody. And I clarified that the liposome significantly inhibited progression of periodontitis in comparison with the simple substance dosage of HMGB1 neutralizing antibody.

Free Research Field

歯周病