2015 Fiscal Year Final Research Report
The association between atherosclerosis and Aa that is a periodontal pathogenic bacteria.
| Project/Area Number |
26861821
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Periodontology
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | Aa / Omp100 / アテローム性動脈硬化症 |
|---|
| Outline of Final Research Achievements |
Periodontal disease has been pointed out relevance to atherosclerosis. The purpose of this study is to analyze the reaction of periodontal pathogenic bacteria Aggregatibactor actinomycetemcomitans and vascular endothelial cells. We found that was increased expression of inflammatory cytokines and adhesion factor of vascular endothelial cells by the supernatant after fracturing A. actinomycetemcomitans. We also found that was promoted adhesion of vascular endothelial cells and monocytes by supernatant after fracturing A. actinomycetemcomitans. Therefore, we suggested that A. actinomycetemcomitans was involved in the pathogenesis of atherosclerosis.
|
| Free Research Field |
歯周病学
|
