Relationship between Cnm-positive Streptococcus mutans and cerebral microbleeds in humans

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861835
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Watanabe Isao 京都府立医科大学, 医学(系)研究科(研究院), 助教 (10636525)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: う蝕原性細菌 / Cnmタンパク / 無症候性脳出血

Outline of Final Research Achievements

We have shown that the surface Cnm protein expressed on cnm-positive Streptococcus mutans is involved in development of CMBs. Two-hundred ninty-seven community residents (70.0 years), were examined for the presence or absence of cnm-positive S. mutans in the saliva by PCR and collagen binding activity, CMBs, and cognitive function were evaluated. Cnm-positive Streptococcus mutans was detected more often among subjects with CMB (p < 0.01) than those without. The risk of CMBs was significantly higher (odds ratio=12.3) in the group with than without S. mutans expressing collagen binding activity. Deep CMBs were more frequent (72%) and cognitive function was lower among subjects with cnm-positive S. mutans expressing collagen binding activity. This work supports the role of oral health in stroke and dementia and proposes a molecular mechanism for the interaction.

Free Research Field

歯科