Development of the sealant which controls pathogenic bacteria of dental caries associated with systemic disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861845
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: The Nippon Dental University
• Principal Investigator: Shimazu Kisaki 日本歯科大学, 生命歯学部, 非常勤講師 (80582254)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: バイオフィルム / う蝕予防 / シーラント / 共凝集 / 自己凝集 / S-PRGフィラー

Outline of Final Research Achievements

Streptococcus gordonii, a bacterium involved in the initial colonization of tooth surfaces, contributes to dental biofilm formation and is an important cause of infective endocarditis. This study aimed to investigate the influence of S-PRG filler on oral bacterial growth and aggregation of S. gordonii. The effect of various concentrations of S-PRG eluate on the growth and the biofilm formation of S. gordonii and other oral microorganisms was assessed. In addition, the effect of S-PRG eluate on coaggregation of S. gordonii with both S. oralis and Fusobacterium nucleatum was assessed. Our results indicate that S-PRG eluate treatment reduced both for the growth and for biofilm of all organisms in a dose-dependent manner. Coaggregation of S. gordonii was inhibited by S-PRG eluate. These results indicate that the S-PRG filler possesses antimicrobial activity that is mediated by inhibiting growth and biofilm of oral microorganisms, and by suppressing coaggregation of S. gordonii.

Free Research Field

口腔微生物学