2016 Fiscal Year Final Research Report
Comprehensive analysis of oral bacterial flora using human evolution model
| Project/Area Number |
26861847
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 人類進化モデル / チンパンジー / 口腔微生物叢 / ピロシーケンス法 / ホールゲノムシークエンス / ミュータンスレンサ球菌 / う蝕 / 歯周疾患 |
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| Outline of Final Research Achievements |
We collected the dental plaque by the sterilized tooth brush, and analyzed them by the culture and metagenomic methods. As the results, we found two similar bacteria (Streptococcus troglotytae and S. dentirousetti) to S. mutans and S. sobrinus as the group of mutans streptococci. Moreover, we found a new species of the group of mitis streptococci, and named as S. panodentis. We analyzed whole genome sequence of the S. troglotytae TKU31, and these pathogenic genes were similar to those of S. mutans. We found the core microbiome of the oral flora in chimpanzees was similar to that in humans.
Momoi et al., described that the dental caries was few, but huge accumulation of the dental plaque in the oral cavity of chimpanzees. Consequently, we confirmed an important factor for the human dental caries progression could be the consumption of the sugar, as previously described. We also supposed to be the oral microbiota coevolve with their host.
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| Free Research Field |
予防歯科学
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