2016 Fiscal Year Final Research Report
Influencing factor for micturition frequency in aged rat
| Project/Area Number |
26861872
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fundamental nursing
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Research Collaborator |
SAKAI AZUKI 山形大学, 大学院医学系研究科看護学専攻
KANNO Sumika 山形大学, 大学院医学系研究科看護学専攻
Goto Nozomi 山形大学, 大学院医学系研究科看護学専攻
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 排尿機能 / 加齢変化 / F344rat / serotonin |
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| Outline of Final Research Achievements |
The question has remained unanswered how the nocturia increases by getting old. Although, there are many influencing factors, some recent studies have suggested that the change of the biological clock causes the nocturia . Therefore the present study was undertaken in order to investigate whether the bladder body contraction by serotonin (5-HT) has influenced with aging in experimental animal. 5-HT is a precursor of the melatonin that is maintaining the biological clock, and it has been reported that the 5-HT-induced contraction has increased in the overactive bladder. Our results suggested that the 5-HT-induced contraction has changed in aged bladder, moreover the mechanism can change.
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| Free Research Field |
基礎看護学
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