Application of emulsion bone paste forming porous structure to periodontal treatment

2016 Fiscal Year Final Research Report

• Project/Area Number: 26870016
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dental engineering/Regenerative dentistry; Periodontology
• Research Institution: Hokkaido University
• Principal Investigator: KATO Akihito 北海道大学, 歯学研究科, 助教 (40507571)
• Research Collaborator: NISHIDA Erika ; TATEYAMA Akito
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 歯周組織再生 / エマルション / 骨ペースト / 多孔質体 / 骨増生効果 / 生体親和性 / イングロース / スキャフォールド

Outline of Final Research Achievements

We developed bone paste using particle emulsion of α-Tricalcium phosphate (α-TCP) and Poly(lactic-co-glycolic) acid (PLGA), and evaluated the ability as bone regeneration material in vivo and in vitro. As a result, emulsion bone paste showed good biocompatibility in vivo, and more cell invasion into the material was observed by PLGA addition. If this new bone paste can be applied to periodontal disease, it is expected that a large amount of cells in the surrounding will invade the material, and it will be possible to obtain the effect of regeneration over conventional bone graft material.

Free Research Field

歯周病学