Low-birth-weight neonate at Great earthquake disaster and genomic imprinting in placenta

2016 Fiscal Year Final Research Report

• Project/Area Number: 26870032
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health; Obstetrics and gynecology
• Research Institution: Tohoku University
• Principal Investigator: Miyauchi Naoko 東北大学, 医学系研究科, 研究支援者 (60596162)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 産科学 / 母子保健 / エピゲノム / インプリンティング / 胎盤

Outline of Final Research Achievements

The low-birth-weight (LBW) baby have increases due to the in appropriate nourishment, lack of exercise and mental distress in pregnant women. It is thought that LBW baby has been developed to the adult disease; life-style disease, several cancers and mental depression. This finding could be an explanation of the epigenetic effect of the placenta. Firstly, we examined to what factors is associated with the LBW babies. Secondly, we performed genome-wide allelic DNA methylation analyses of purified trophoblast cells from human placentas. RNA sequencing-based allelic expression analyses revealed whether imprinted gene expression is correct or not. We found the LBW risk was associated with smoking and loss of imprinting in their placenta cells (80%).

Free Research Field

分子生物学