2017 Fiscal Year Final Research Report
The basic study that aimed at elucidation of pathological mechanism and new regulation techniques of the intractable oral mucosa disease
| Project/Area Number |
26870170
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
Morphological basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 口腔扁平苔癬 / PD-1陽性T細胞 / 基底細胞 / PD-L1 |
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| Outline of Final Research Achievements |
Oral lichen planus (OLP) is a common chronic inflammatory mucosal disease. While the pathophysiology of OLP is not clearly understood, it is characterized by a dense subepithelial infiltration of activated CD4 and CD8 T cells and a hydropic degeneration of the basal epithelial cells (keratinocytes). The costimulatory signals which can be either positive or negative and the large amount of cytokines released from various cells contribute to the regulation of T cell immune responses.
We observed that PD-1 was expressed on subepithelial infiltrating CD3 positve T cells in OLP lesion. In addition, PD-L1 expression was induced on the keratinocytes located close to the infiltrates. These results suggested that PD-1 on T cells - PD-L1 on keratinocytes interaction contributed to the regulation of immune responses in OLP lesion.
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| Free Research Field |
口腔外科
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