Effect of oxygen nanobubbles water on avulsed and replanted teeth for conservative therapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 26870173
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry; Orthodontics/Pediatric dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: OISHI Atsushi 東京医科歯科大学, 歯学部附属病院, 医員 (50645166)
• Research Collaborator: TAKAHASHI Masayoshi 産業総合研究所, 主任研究員 ; ARAKAWA Shinichi 東京医科歯科大学, 生涯口腔保健衛生学分野, 教授 ; SHIMOKAWA Hitoyata 東京医科歯科大学, 小児歯科学分野, 非常勤講師
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: ナノバブル / マイクロバブル / ウルトラファインバブル / 歯の外傷 / 歯小嚢 / 細胞培養

Outline of Final Research Achievements

This study investigated the efficacy of oxygen nanobubble water to encourage proper healing of traumatized teeth. In the beginning of this study, previous studies about nanobubble water reported its bioactive effect by the increase of survival rate etc, and the mechanism to living organisms was not fully elucidated. Additionally, renovation of our animal laboratory building was postponed. Therefore, our initial experiment plan required significant change, and we inspected the effect of nanobubble water on human oral tissue as a previous step of therapeutic application of nanobubble water to traumatized teeth. Oxygen and air nanobubble water inhibited the proliferation of human dental follicle stem cells in vitro. However, comprehensive elucidation of the effects of air and oxygen nanobubble water on oral tissue and living organisums will require further investigation both in vitro and in vivo.

Free Research Field

小児歯科学