A comprehensive analysis of ion transport molecule for the physiological role in the cochlear epithelial layer.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26870210
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology; General physiology
• Research Institution: Niigata University
• Principal Investigator: OGATA GENKI 新潟大学, 研究推進機構, 助教 (80452829)
• Research Collaborator: HIBINO Hiroshi 新潟大学, 医歯学系, 教授 (70314317) ; NIN Fumiaki 新潟大学, 医歯学系, 准教授 (80644905) ; NAGAMORI Shushi 大阪大学, 医学系研究科, 准教授 (90467572) ; YOSHIDA Takamasa 新潟大学, 医歯学総合研究科, 大学院生 ; UETSUKA Satoru 新潟大学, 医歯学総合研究科, 大学院生
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 蝸牛 / 血管条 / 内リンパ液 / チャネル / トランスポータ

Outline of Final Research Achievements

Endolymph, which is the fluid contained in the inner ear, always shows the high potential of +80 mV. The decrease of endocochlear potential cause the hearing loss. This high potential is dependent on both of the potential and the ionic concentration behavior of the stria vascularis, which consists of two layer of epithelial tissues, the inner and the outer layer. In this study, we identified 104 ionic transport molecules which contribute to the ionic behavior of the stria vascularis. In addition, we identified that the sodium ionic transportation of the outer layer of the stria vascularis is important for maintaining the endocochlear potential by using the electrophysiological experiments and the computer simulation analysis.

Free Research Field

生理学一般 / 薬理学一般