2016 Fiscal Year Final Research Report
New preventive strategy of bronchopulmonary dysplasia with geranylgeranylacetone
| Project/Area Number |
26870229
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
Embryonic/Neonatal medicine
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| Research Institution | University of Fukui |
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Principal Investigator |
Tokuriki Shuko 福井大学, 学術研究院医学系部門, 助教 (60510237)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | heat shock protein / geranylgeranylaceton / premature infant / hyperoxia / alveolarization |
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| Outline of Final Research Achievements |
We investigated whether geranylgeranylacetone(GGA) protected neonatal lungs from hyperoxic stress in a murine bronchopulmonary dysplasia (BPD) model, and measured serum heat shock protein (HSP)70 levels in preterm humans treated with oxygen. GGA administration enhanced HSP70 expression two-fold compared with normoxia-exposed and vehicle-treated mice. Hyperoxia reduced HSP70 expression, whereas GGA abrogated the effects. Hyperoxia-exposed mice exhibited more apoptotic cells in lung parenchyma and a more simplified alveolar structure with less radial alveolar count (RAC) and larger mean linear intercept (MLI) than normoxia-exposed mice. GGA suppressed the increase in apoptotic cells and the structural changes of the lungs induced by hyperoxia. Serum HSP70 levels of preterm human infants gradually decreased with age.GGA may attenuate hyperoxic injury in neonatal lungs and thereby may prevent the development of BPD.
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| Free Research Field |
neonatology
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