2016 Fiscal Year Final Research Report
Ca2+ oscillation in cortical astrocytes influence on brain development
Project/Area Number |
26870256
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Morphology/Structure
General physiology
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
Mutoh Hiroki 浜松医科大学, 医学部, 助教 (60443040)
|
Co-Investigator(Renkei-kenkyūsha) |
Fukuda Atsuo 浜松医科大学, 医学部, 教授 (50254272)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | astrocyte / calcium imaging / cortical development |
Outline of Final Research Achievements |
The interactions between neurons and glial cells have physiological importance in the brain function and development. However, it has not been well elucidated. In this study, we investigated a role of astrocyte, major type of glial cells in the central nervous system, in brain development by monitoring rhythmic fluctuations in the concentration of intracellular calcium in association with spontaneous, commonly referred to as calcium oscillation. It has turned out that calcium oscillation in astrocytes tended to increase the frequency with the cerebrocortical development. Currently, it still continues to be accumulating and analyzing calcium oscillation in astrocytes from various ages of mice with a view to understanding control mechanism of calcium oscillation and its influence on brain development.
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Free Research Field |
神経科学
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