Molecular and neural bases of memory updating in <i>C. elegans</i>

2016 Fiscal Year Final Research Report

• Project/Area Number: 26870266
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology; Neurophysiology / General neuroscience
• Research Institution: Nagoya University
• Principal Investigator: Aoki Ichiro 名古屋大学, 理学研究科, 研究員 (60725258)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: <i>C. elegans</i> / 温度走性行動 / 記憶 / カリウムチャネル / CNGチャネル / BKチャネル / 神経回路 / てんかん

Outline of Final Research Achievements

Updating memory and changing behavior at the right time is crucial for animals to survive in constantly fluctuating environments. In order to elucidate molecular and neural mechanisms underlying memory updating, a forward genetic screen was performed on plasticity of thermotaxis behavior of <i>C. elegans</i>. SLO-2, a potassium channel involved in a pathogenesis of several types of epilepsies, was found to regulate the speed of memory updating.

Free Research Field

分子神経生物学