• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2015 Fiscal Year Final Research Report

Functional analysis of protein disulfide isomerase P5 as anti-cancer target

Research Project

  • PDF
Project/Area Number 26870287
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Drug development chemistry
Biological pharmacy
Research InstitutionKyoto University

Principal Investigator

HORIBE TOMOHISA  京都大学, 医学(系)研究科(研究院), 講師 (20467468)

Project Period (FY) 2014-04-01 – 2016-03-31
Keywordsケミカルバイオロジー / タンパク質 / 分子シャペロン
Outline of Final Research Achievements

We performed the functional analysis of protein disulfide isomerase (PDI) P5 in cancer cells using inhibitors to reductase activity of P5, which we previously screened and identified using a chemical compound library. It was found that one of these inhibitors could decrease the secretion levels of soluble MICA from cancer cells. We also examined the effect of the inhibitors on the cancer cells viability, and found that the inhibitors had cytotoxic activity to cancer cells.

Free Research Field

分子生物学

URL: 

Published: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi