2015 Fiscal Year Final Research Report
Development of fluorescent sensors to quantitatively detect signal molecules in single cells
| Project/Area Number |
26870291
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bio-related chemistry
Chemical biology
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| Research Institution | Kyoto University |
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Principal Investigator |
Sakaguchi Reiko 京都大学, 物質-細胞統合システム拠点, 助教 (80723197)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | ケミカルバイオロジー |
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| Outline of Final Research Achievements |
Living organism utilize various signaling molecules to regulate themselves. Among them, InsPns are known to regulate intracellular Ca2+ concentrations and control cellular responses such as transcription and translation. Individual InsPns are very similar to each other, with only subtle differences. Nevertheless, they each play their own roles as a signaling molecule. Therefore, it will be useful to develop a technique that can monitor each of the InsPns in a live cell in real time. In this study, we have developed fluorescence based sensors that can specifically monitor several InsPns, to elucidate their physiological roles.
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| Free Research Field |
生体関連化学
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