In-vivo imaging of proliferation, invasion and metastasis of brain metastatictumor model

2015 Fiscal Year Final Research Report

• Project/Area Number: 26870339
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science; Medical Physics and Radiological Technology
• Research Institution: Osaka University
• Principal Investigator: Saito Shigeyoshi 大阪大学, 医学(系)研究科(研究院), 助教 (40583068)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 生体イメージング / 磁気共鳴医学

Outline of Final Research Achievements

The purpose of this study is in-vivo imaging of ｐroliferation, invasion and metastasis of brain metastatictumor model. A brain metastatic tumor model were established from breast cancer tumor. At each stage of growth, migration, invasion and metastasis from the primary tumor, the in-vivo imaging such as 11.7T-MRI, 1.5T-MRI, Micro-CT and fluorescence imaging for non-invasive evaluation. In addition, the factors involved in the growth and metastasis of tumor cells ere claryfied using the molecular biological techniques such as PCR, western blot, flow cytometry and immunohistochemical staining. We established non-invasive evaluation of brain metastatictumor model by in-vivo imaging .

Free Research Field

放射線技術学