Analysis of a novel molecular mechanism on apoptosis regulation of FA proteins

2015 Fiscal Year Final Research Report

• Project/Area Number: 26870356
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Molecular biology; Cell biology
• Research Institution: Kobe University
• Principal Investigator: SAKAI Wataru 神戸大学, バイオシグナル総合研究センター, 助教 (70526251)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: ファンコニ貧血 / アポトーシス

Outline of Final Research Achievements

Fanconi anemia (FA) is rare genetic disorder characterized by genome instability. Molecular mechanism of FA proteins is generally focused on the DNA damage response and repair. However, mechanisms of some FA symptoms are still unknown. In the pilot study, I revealed a novel possibility that a FA protein function in regulation of cell death. In this study, the possibility was verified more detail, and implying that a novel mechanism of FA proteins as a negative regulator of apoptosis in DNA damage independent manner. Furthermore, to explore the novel regulation of FA proteins, I challenged isolation of unknown FA-interaction proteins. The comprehensive screening identified more than 100 candidates as novel FA interacting proteins. Gene ontology analysis showed that about 10% of those candidates belong to a specific pathway, unrelated to classic FA pathway.

Free Research Field

DNA損傷修復