2016 Fiscal Year Final Research Report
Neural basis of apathy: multiple MRI approaches
| Project/Area Number |
26870375
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic / Social brain science
Experimental psychology
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| Research Institution | Shimane University |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | アパシー / 安静時fMRI |
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| Outline of Final Research Achievements |
Apathy is a state without motivation, and defined as diminished or decreased goal-directed behavior. This study aimed to investigate the neural mechanism of apathy using multiple approaches. In a resting-state fMRI analysis for healthy elderly, apathy is associated with executive function, and involved in decreased functional connectivity between lateral prefrontal cortex and basal ganglia. Also, an another experiment revealed that the functional connectivity between basal ganglia and supplemental motor area is related with apathy in healthy elderly. These evidences suggested that multiple frontal-basal ganglia loops are involved in apathy.
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| Free Research Field |
認知神経科学
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