Development of Juvenile Hormone Antagonist Controlling Insect Metamorphosis and Elucidation of the Mechanism of its Action

2016 Fiscal Year Final Research Report

• Project/Area Number: 26870380
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plant protection science; Bioorganic chemistry
• Research Institution: Shimane University
• Principal Investigator: FURUTA Kenjiro 島根大学, 生物資源科学部, 助教 (00575532)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 幼若ホルモン / Methoprene-tolerant / アンタゴニスト

Outline of Final Research Achievements

Juvenile hormone is an insect hormone that regulates various physiological mechanisms such as molting and metamorphosis. Therefore, its receptor Methoperen-tolerant (Met) is attracting attention as a target molecule for new insect growth regulators. In this study, we have studied for the purpose of developing a JH antagonist that suppresses function of Met by directly binding.
We synthesized various compounds by organic synthesis and examined their biological activities by precocious metamorphosis-inducing activity test against silkworm larva and the binding test to Met protein of the silkworm. As a result, we found compound NY04 as a novel JH antagonist.

Free Research Field

生物有機化学