2015 Fiscal Year Final Research Report
Eicosapentaenoic acid for browning effect through GPR120
| Project/Area Number |
26870401
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
Metabolomics
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| Research Institution | Hiroshima University |
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Principal Investigator |
Haruya Ohno 広島大学, 医歯薬保健学研究院(医), 助教 (60725894)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 褐色脂肪細胞 / ベージュ脂肪細胞 |
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| Outline of Final Research Achievements |
We investigated the effect of Eicosapentaenoic acid on brown fat functions through one of its receptor, GPR120. GW9508, a specific GPR120 agonist, elevated brown fat specific genes including Ucp-1 in brown adipocytes. Knockdown of GPR120 or addition of MEK1/2 inhibitors canceled the activating effect of GW9508. Eicosapentaenoic acid might activate brown adipocytes through the GPR120 and MAPK pathway.
Morphological and gene expression analyses in perirenal adipose tissue in pheochromocytoma patients revealed that EHMT1, a histon methyltransferase, might play an important role for developing brown adipocytes in adult human.
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| Free Research Field |
代謝
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