Establishment of quantification method of pulmonary blood flow in patients with COPD using Dual-energy CT images

2016 Fiscal Year Final Research Report

• Project/Area Number: 26870436
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine; Radiation science
• Research Institution: Nagasaki University
• Principal Investigator: KOIKE Hirofumi 長崎大学, 病院(医学系), 医員 (30725643)
• Research Collaborator: SAKAMOTO Ichiro 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (00225806)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 論文提出 / 肺気腫 / 肺血栓症

Outline of Final Research Achievements

Respiratory function tests and CT examinations have been mainly used for evaluation of patients with COPD, but they are said to have little correlation with severity and prognosis, and it is considered that a new modality is required. Dual-energy CT can visualize and quantify the distribution of iodine contrast agent in the lung, and it is said that there is a correlation with blood flow. Sixty-two subjects were divided into two groups: with (n=14) and without (n=48) COPD. We evaluated the quantification of lung PBV. Lung PBV values were 20.1±5.5 and 30.6±7.6 in those with and without COPD, respectively, with a significant difference between them (p<0.0001). Quantification of lung PBV reflects reduced pulmonary perfusion in patients with COPD.

Free Research Field

放射線科学