The impact of a high dietary fructose intake on intestinal homeostasis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26870459
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits; Gastroenterology
• Research Institution: Kagoshima University
• Principal Investigator: Kanmura Shuji 鹿児島大学, 医歯学域附属病院, 講師 (60448561)
• Research Collaborator: IDO Akio ; KAWABATA Katsuto
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: フルクトース / 腸管維持機構 / タイトジャンクション

Outline of Final Research Achievements

Fructose is an inverted sugar which is used in popular beverages and recently its consumption has rapidly increased. The excessive intake of fructose is a well known risk factor for obesity and arteriosclerosis, however, it has not been previously evaluated regarding its effect on the intestinal tract. We herein analyzed the impact of fructose on the intestinal barrier function in a experimental colitis model mouse.
The pathology and disease activity index score in a high fructose diet group significantly increased in comparison to a normal diet group, and the tight junction protein expression of occludin significantly decreased in in a high fructose diet. A high concentration of fructose was therefore found to affect the tight junctions of epithelial cells, while also causing the intestinal barrier function to worsen.

Free Research Field

消化管