2016 Fiscal Year Final Research Report
A novel treatment for breast cancer using intrinsic magnetized taxol
| Project/Area Number |
26870481
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
Tumor therapeutics
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 磁性 / 乳がん / がん治療 / ドラッグデリバリー / MRI |
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| Outline of Final Research Achievements |
We previously reported a novel magnetic organic compound, N,N’-bis(salicylidene)ethylenediamine iron Fe(Salen), as an anti-cancer agent with intrinsic magnetic property. We identified the magnetic chemical key structure of Fe(salen) generating the magnetic property using Super Photon ring-8 GeV (Spring 8) (RIKEN). Here, we have designed specific covalent linkage of the Fe(Salen), to a commercial available drug, such as PTX. Fe(Salen) serves as a magnetically-responsive scaffold, generating the magnetic property in addition to the classic cytotoxic property of PTX. Our aim is to developing a novel treatment using M-PTX on cancer including breast cancer.
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| Free Research Field |
創薬
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