The change of gut immunity by exercise: the relationship between the antimicrobial peptide "defensin" and the gut microbiota.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26870499
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science; Sports science
• Research Institution: Aichi Toho University
• Principal Investigator: Tanimura Yuko 愛知東邦大学, 人間健康学部, 助教 (90551458)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 自発運動 / デフェンシン / 腸内細菌

Outline of Final Research Achievements

The aim of the current study was to examine how exercise changes the antimicrobial peptides "α-defensin" (known as cryptdin in mice), as well as the microbiota in the gut of mice, to determine how a change to the microbiota affects the expression of cryptdin in the gastrointestinal tract. Our results showed that cryptdin-4 expression in the small intestine decreased with sixteen weeks of voluntary wheel exercise, while a high-fiber diet had no effect. Although exercise and a high- fiber diet affected a change in the microbiota, this change did not affect the expression of cryptdin‐4 in the small intestine.

Free Research Field

運動免疫学