2017 Fiscal Year Final Research Report
Multiple comparative analysis of FXR-inhibitory effect on liver carcinogenesis
| Project/Area Number |
26870501
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
Pathological medical chemistry
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Research Collaborator |
IKEDA Kazuo
KAWADA Norifumi
TERANISHI Yuga
ODAGIRI Naoshi
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | FXR / 肝星細胞 / 肝硬変 / 肝がん |
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| Outline of Final Research Achievements |
In this study, a molecular analysis of Farnesoid X receptor (FXR)-inhibitory effects in HSC activation was performed, to unveil a molecular mechanism by which liver cirrhosis induces liver carcinogenesis. Hepatic stellate cells (HSCs) were found to express FXR more highly than the other liver component cells. Lithocholic acid showed suppression of human HSC activation among major bile acids (cholic acid, chenodeoxycholic acid, deoxycholic acid, ursodeoxycholic acid). A synthetic FXR activator GW4064 also showed the suppression of human HSC activation, but another synthetic FXR activator obeticholic acid did not. These results may suggest plural pathways (or forms) of the FXR activation, although a detailed study is required.
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| Free Research Field |
肝臓病学
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