Bioavailability and bioactivity of dietary polyphenols.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26870506
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Food science; Eating habits
• Research Institution: University of Hyogo
• Principal Investigator: Ishisaka Akari 兵庫県立大学, 環境人間学部, 助教 (30724463)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ポリフェノール / フラボノイド / ケルセチン / 脱抱合 / 炎症

Outline of Final Research Achievements

Quercetin is the major polyphenol included in various fruits and vegetables. To understand the localization and target sites of quercetin underlying the bioactivity in vivo, we planned to develop monoclonal antibodies directed to quercetin aglycone and its degradation product. However, the developed antibodies scarcely recognized the haptens. These results suggested that the antibodies were difficult to available for immunochemical studies. On the other hands, we investigated the deconjugation mechanism of quercetin metabolites in healthy/inflammation animal models. This study suggested that the deconjugation of quercetin metabolites at sites of inflammation was contributed to the anti-inflammatory activity in vivo.

Free Research Field

食品機能学