2015 Fiscal Year Final Research Report
The molecular basis of novel bone regeneration methods by regulating TLE3
| Project/Area Number |
26870543
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Functional basic dentistry
Surgical dentistry
|
|---|
| Research Institution | Kyushu Dental College |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 再生医学 / 運動器 / 骨 / 骨格筋 |
|---|
| Outline of Final Research Achievements |
Groucho/TLE family members are transcriptional co-factors in metazoans that play critical roles during development and cell fate determination. We recently reported that TLE3, one of the Groucho/TLE family members, regulates the balance between osteoblast and adipocyte formation from mesenchymal stem cells (Kokabu S et al., 2013).
Here, we reported that canonical Wnt signaling increases the expression levels of TLE3 while TLE3 suppresses canonical Wnt signaling in bone marrow mesenchymal stem cells (Kokabu S et al., 2014). We also suggested the possibility that TLE expresses by satellite cells, skeletal muscle stem cells, and interacts with the bHLH domain of MyoD and interferes with the formation of a complex between MyoD and E-protein, which consequently results in repression of MyoD transcriptional activity and myogenesis.
|
| Free Research Field |
骨・骨格筋代謝
|
