Prevention of hepatic fat accumulation by habitual exercise and dietary restriction: Examination of a novel mechanism via adipose tissue

2017 Fiscal Year Final Research Report

• Project/Area Number: 26870553
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits; Applied health science
• Research Institution: Wayo Women's University
• Principal Investigator: Kurosaka Yuka 和洋女子大学, 生活科学系, 助手 (30633002)
• Research Collaborator: MINATO Kumiko ; SHIROYA Yoko ; YAMAUCHI Hideki
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 脂肪肝 / 肥満 / 運動習慣 / 食事制限 / 脂肪細胞サイズ

Outline of Final Research Achievements

In this study, we focused on adipocyte size and function to elucidate a novel means of preventing fatty liver development by habitual exercise and dietary restriction.
Fatty liver development was suppressed by a combination of habitual exercise and dietary restriction, but not by dietary restriction alone. Differences in adipocyte size and function were detected following combination of habitual exercise and dietary restriction versus dietary restriction alone. Weight management strategies that depend solely on dietary restriction may disrupt communication pathways related to fat metabolism between adipose tissue and the liver, thereby promoting the development of a fatty liver. By incorporating exercise, it is possible that this disruption can be avoided, and fatty liver development may be prevented.

Free Research Field

運動・栄養生理学