Determination of the most effective carbohydrate content in diabetic diet therapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 26870556
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science; Eating habits
• Research Institution: Seitoku University
• Principal Investigator: Fukatsu Akiko 聖徳大学, 人間栄養学部, 講師 (10709778)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 低炭水化物食 / 食事脂肪 / 食後高血糖 / インスリン抵抗性 / 糖質代謝 / 脂質代謝 / アディポサイトカイン / 体組成

Outline of Final Research Achievements

We examined the effect of a low-carbohydrate, high-fat diet (LCHF diet; 30% carbohydrates, 45% fat) on the postprandial glucose response in healthy subjects. Although the LCHF diet improved postprandial glucose tolerance, in the second-meal analysis, increased the glucose response and the concentration for serum non-esterified fatty acids (NEFAs) and insulin. We concluded that LCHF meals induced insulin resistance at the second meal with increased NEFAs.
Subsequently, we evaluated the effect of a 7-day moderately low-carbohydrate diet (MLC diet; 40% carbohydrates, 35% fat) on glucose and lipid metabolism. The MLC diet decreased serum triglyceride and adiponectin levels and did not alter serum low-density lipoprotein cholesterol.
We concluded that we should plan low-carbohydrate diets considering the effects of fat on glucose and lipid metabolism. These findings need to be confirmed in longer-term studies that also include subjects with diabetes.

Free Research Field

臨床栄養学