Analysis of the mechanisms of pathogenesis and eradication response in Helicobacter pylori-associated immune thrombocytopenia

2015 Fiscal Year Final Research Report

• Project/Area Number: 26870561
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology; Laboratory medicine
• Research Institution: Kitasato University
• Principal Investigator: SATOH Takashi 北里大学, 医療衛生学部, 講師 (90407114)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 免疫性血小板減少症 / Helicobacter pylori

Outline of Final Research Achievements

In this study, the associations between gene polymorphisms and rates of Helicobacter pylori (H. pylori) eradication response in patients with H.pylori-associated immune thrombocytopenia (ITP) were evaluated. Patients with ITP who were carriers of the FcγRIIB 232T or TGF-β -509T polymorphisms had significantly higher rates of H. pylori eradication responses than non-carriers. The frequency of the circulating anti-glycoprotein IIb/IIIa antibody-producing cells was significantly higher in patients with ITP that carried the FcγRIIB 232T allele than in those with the non-T allele. In addition, patients with ITP that carried the TGF-β -509T allele tended to have lower TGF-β levels. These findings suggest that FcγRIIB 232I/T and TGF-β -509C/T gene polymorphisms contribute to the susceptibility of H.pylori-associated ITP by controlling the autoimmune responses.

Free Research Field

血液検査学