Micro-imaging of the intratumoral boron distribution in the neutron capture therapy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26870563
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery; Medical Physics and Radiological Technology
• Research Institution: Kyorin University
• Principal Investigator: Sato Eisuke 杏林大学, 保健学部, 助教 (00439150)
• Research Collaborator: ISOBE Tomonori 筑波大学, 医学医療系, 准教授 (70383643) ; YAMAMOTO Tetsuya 筑波大学, 医学医療系, 准教授 (30375505)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: MRI / 1H-MRS / BNCT

Outline of Final Research Achievements

The effect of treatment of BNCT greatly depends on quantity of the boron taken in by intratumorale boron and the distribution. A purpose of this research is to establish the micro-imaging techniques of the intratumoral boron distribution.
Firstly I classified the Cho/Cr value acquired using 1H-MRS in four stages according to the grade of the brain tumor. And Cho/Cr value allotted to four colors was imaged in each voxel. As a result, the image of the Cho/Cr value matched up to a T2-weighted image. It means that the border with a normal region and the tumor region was distinguished clearly. Furthermore, it was confirmed that the intratumoral grade was heterogeneous.

Free Research Field

MRI, 1H-MRS, BNCT