2015 Fiscal Year Final Research Report
Neurorepair after ischemic stroke by hematopoietic cells
| Project/Area Number |
26870571
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
General internal medicine(including psychosomatic medicine)
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 脳梗塞 / 炎症 / マクロファージ / 自然免疫 |
|---|
| Outline of Final Research Achievements |
Stroke is a leading cause of death and disability worldwide, and approximately 70% of stroke are ischemic stroke. The approved treatments for ischemic stroke are limited within the early time after stroke onset. There is a need for an efficacious therapy which can be administered in the delayed phase of ischemic stroke. Post-ischemic inflammation is an essential step in the pathologies of ischemic stroke. The secondary progression of the infarct lesion by inflammation is directly linked to the prognosis of ischemic stroke patients. In this research, we clarified the molecular mechanisms in the resolution of cerebral post-ischemic inflammation to establish novel therapeutic strategies for ischemic stroke.
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| Free Research Field |
免疫学
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