2015 Fiscal Year Final Research Report
Development of novel skin moisturizer, activating Caspase 14 expression
| Project/Area Number |
26870610
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Dermatology
Biological pharmacy
|
|---|
| Research Institution | Tokyo Denki University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | カスパーゼ / スフィンゴイド塩基 / MAPキナーゼ / 皮膚 / 保湿 |
|---|
| Outline of Final Research Achievements |
We evaluated the mechanism of skin moisture maintaining system involving sphingoid bases. Sub-micromolar doses of sphingoid bases treatment, that doses do not damage cells, were treated on human keratinocyte cells. Caspase-14 mRNA level and protein level was upregulated dose-dependently on HaCaT cells. Furthermore, sphingoid bases-induced caspase-14 was involved of MAPK, especially JNK and p38.
Affecting sphingoid bases to mouse skin resulted in upregulation of caspase-14, presuming that sphingoid bases could maintain skin barrier in vivo.
|
| Free Research Field |
生化学
|
