New treatment strategy against skeletal muscle atrophy using combination of stretching and heat stimulation for patients on steroid

2016 Fiscal Year Final Research Report

• Project/Area Number: 26870691
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science; Rehabilitation science/Welfare engineering
• Research Institution: Nihon Fukushi University
• Principal Investigator: TSUCHIDA Wakako 日本福祉大学, 健康科学部, 助教 (90610014)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ステロイド / 筋萎縮 / 熱刺激 / ストレッチ / 骨格筋

Outline of Final Research Achievements

This study aimed to investigate the effects of combination of stretching and heat stimulation on the steroid-induced muscle atrophy in vitro and vivo. The results demonstrate that heat stimulation can prevent the progression of skeletal muscle atrophy, and this effect is linked to the modulation of both catabolic and anabolic signaling pathways. The study also suggests that stretching induce skeletal muscle hypertrophy, possibly through the activation of anabolic signaling pathways. Hence, the combination of the heat stimulation and stretching may be effective in steroid-induced muscle atrophy.

Free Research Field

骨格筋分子生物学