2016 Fiscal Year Final Research Report
Improvement of therapeutic resistance of glioma stem cells by 5-ALA photodynamic therapy
Project/Area Number |
26870722
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Tumor therapeutics
Neurosurgery
|
Research Institution | Osaka Medical College |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 光線力学治療 / 光線力学診断 / 5-アミノレブリン酸 / ポルフィリン / ABCG2 / 腫瘍幹細胞 / 悪性神経膠腫 / 脳腫瘍 |
Outline of Final Research Achievements |
Terapeutic resistance to radiation therapy and chemotherapy of glioma stem cells is a major hurdle in the treatment of malignant glioma. In this study, ALA-PDT was performed using glioma stem cell lines (3 cell lines of mesenchymal type and 2 cell lines of proneural type). As a result, it was found that ALA-PDT is more sensitive to glioma stem cells and has superior characteristics such as decreased stemness after PDT treatment.
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Free Research Field |
脳神経外科
|