2016 Fiscal Year Final Research Report
Development of a convenient assay for cell-mediated immunity to the influenza virus.
| Project/Area Number |
26870758
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Laboratory medicine
Epidemiology and preventive medicine
|
|---|
| Research Institution | Hyogo Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | インフルエンザ / ワクチン / 細胞性免疫 / 抗体 |
|---|
| Outline of Final Research Achievements |
It is considered that immunological evaluation of the effect of influenza vaccines cannot be performed based on the antibody titer. In this study, using a new cell-mediated immunity measurement method, we investigated changes in the level of IFN-γ produced after vaccination in response to the vaccine antigen in 23 adults. Four subjects were infected with influenza A(H3N2) during the study period, and vaccination did not increase IFN-γ in these 4 subjects. It was suggested that the efficacy of influenza vaccines can be evaluated by measuring changes in the level of IFN-γ produced in response to influenza vaccine.
|
| Free Research Field |
感染症疫学
|
