New approach to treat stroke by assessing cerebral small vessel dysfunction indicated by pulse wave velocity and biomarkers

2016 Fiscal Year Final Research Report

• Project/Area Number: 26870765
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine; Cardiovascular medicine
• Research Institution: National Center for Geriatrics and Gerontology (2015-2016); Kawasaki Medical School (2014)
• Principal Investigator: SAJI Naoki 国立研究開発法人国立長寿医療研究センター, もの忘れセンター, 副センター長 (30624910)
• Research Collaborator: TONE Shigenobu 東京電機大学, 理工学部生命理工学系分子発生生物学研究室, 教授 (70211399) ; SAKURAI Takashi 国立研究開発法人国立長寿医療研究センター, もの忘れセンター, センター長 (50335444)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脳小血管病 / 脳梗塞 / バイオマーカー / 脈波

Outline of Final Research Achievements

Increase of pulse wave velocity (PWV) detriments blood vessels and can cause cerebrovascular, cardiovascular diseases. The aim of this study is to clarify the association between PWV and blood vessel function in patients with cerebrovascular diseases. We assessed patient’s clinical features, PWV, and blood biomarkers such as high sensitivity C-reactive protein, interleukin-6, and matrix metalloproteinase-9. We found that patient’s clinical features and outcomes are associated with PWV and biomarkers. These findings may contribute to predict patient’s outcome and to develop new treatment for stroke.

Free Research Field

脳血管障害と認知機能障害