Functional analysis of neuronal intracellular aggregation by FKBP5

2015 Fiscal Year Final Research Report

• Project/Area Number: 26870846
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Functional biochemistry; Neurochemistry/Neuropharmacology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Sato Ko 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (90610395)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 細胞内凝集 / 分子シャペロン

Outline of Final Research Achievements

The aim of this study is to elucidate whether a molecular co-chaperone protein FK506 binding protein 5 (FKBP5) could be an ‘accelerator of intracellular aggregation’ in neurodegenerative diseases. In this study, I found that over expression of FKBP5 in Alzheimer’s disease model mouse show increase expression levels, highly phosphorylation and miss-localization of tau, a microtubule associated protein. On the other hand, I could not detect intracellular aggregation of tau. These results suggest that FKBP5 would not accelerate intracellular aggregation but modify Alzheimer’s disease pathology.

Free Research Field

機能生物化学