Comprehensive analysis and biomarker identification of osteoarthritis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26870851
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical genome science; Orthopaedic surgery
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Lee Ming Ta 国立研究開発法人理化学研究所, 統合生命医科学研究センター, チームリーダー (70644483)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: osteoarthritis / methylation / epigenetics

Outline of Final Research Achievements

The aim of this project was to identify methylation changes during osteoarthritis disease progression in both the cartilage and subchondral bone.
Methylation profiling was performed on 12 patients with total of 96 data points from both subchondral bone and cartilage. We found that the methylation patters were different in these two tissue. Data suggested that methylation changes in the subchondral bone occurs before the cartilage. Not all the methylation changes led to changes in gene expression, indicating the complex regulation of gene expression. We also identify many transcription factors, such as the homeobox genes strongly indicating the regeneration of repair during the late stages of the disease.

Free Research Field

osteoarthritis