Genomic profiling of large-cell neuroendocrine cartinoma of the lung for the development of new targeted therapies

2015 Fiscal Year Final Research Report

• Project/Area Number: 26870876
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology; Tumor therapeutics
• Research Institution: National Cancer Center Japan
• Principal Investigator: Umemura Shigeki 国立研究開発法人国立がん研究センター, 東病院呼吸器内科, 医員 (80623967)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 分子標的薬 / 癌遺伝子 / 大細胞神経内分泌癌

Outline of Final Research Achievements

Little is known about the molecular features of large-cell neuroendocrine carcinoma of the lung (LCNEC). We performed targeted capture sequencing of 78 LCNEC samples (65 surgically resected cases and 13 advanced cases) and obtained the overview of the biologically relevant genetic alterations of LCNEC. We found a relatively high prevalence of inactivating mutations in TP53 and RB1 in the same way as SCLC. Genetic alterations in the PI3K/AKT/mTOR pathway were detected in 13 (17%) of the tumors and other well-known activating alterations were detected in EGFR (1 case, 1%) and ERBB2 (1 case, 1%). LCNEC had a similar genomic profile to SCLC, including promising therapeutic targets such as the PI3K/AKT/mTOR pathway and other well-known gene alterations.

Free Research Field

呼吸器内科学