2016 Fiscal Year Final Research Report
Can heart rate variability analysis determine the cardiac recovery on ventricular assist device?
| Project/Area Number |
26870922
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
General surgery
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| Research Institution | Tottori University (2015-2016)
National Cardiovascular Center Research Institute (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 補助人工心臓 / 心拍変動解析 / 心不全 |
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| Outline of Final Research Achievements |
Some patients who need to implant a left ventricular assist device (LVAD) due to severe heart failure may recover cardiac function and reach LVAD withdrawal. With LVAD, no indicator has been established to evaluate true heart function when stopping assistance. We focused on heart rate variability (HRV) analysis which estimating cardiac autonomic nervous function from electrocardiogram. In this study, a heart failure model was introduced for three goats and then LVAD was implanted, and the relationship between cardiac function and HRV was analyzed every week after operation. One goat was observed for 6 weeks after implanting LVAD. Recovery of cardiac function and an upward trend of HRV index were observed. It was suggested that hear rate variability may reflect cardiac function. In addition, we have prepared a system that can measure HRV even in clinical practice.
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| Free Research Field |
心臓血管外科、補助循環
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