Kinetics of phenolic and methoxylated organohalogen compounds in lactation mouse and their infant-exposure assessment

2015 Fiscal Year Final Research Report

• Project/Area Number: 26881008
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Daiichi University, College of Pharmaceutical Sciences
• Principal Investigator: Fujii Yukiko 第一薬科大学, 薬学部, 助教 (80733542)
• Co-Investigator(Renkei-kenkyūsha): HARAGUCHI Koichi 第一薬科大学, 薬学部, 教授 (00258500)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: 母乳分泌 / 衛生学 / マウス / 体内動態 / 環境保健 / トキシコロジー

Outline of Final Research Achievements

Triclosan　(OH-TCS) is a phenolic organohalogen compound, which has been used for antibacterial agents. In this study, we administrated OH-TCS and methoxylated triclosan (M-TCS) to lactation mouse. After administration, 1) OH-TCS were metabolized to dihydroxide TCS (OH-OH-TCS). 2) M-TCS were metabolized to OH-TCS, OH-M-TCS, and OH-OH-TCS. OH-TCS were mainly distributed to blood and liver of the lactation mouse. On the other hands, M-TCS were mainly distributed to their adipose tissue and mammary gland. Administrated M-TCS were also detected in breast milk indicating the infant transfer via breast milk.

Free Research Field

衛生学・環境保健