定量的血栓測定によるステント血栓化予測に有効な血行力学パラメータの抽出

2015 Fiscal Year Annual Research Report

• Project/Area Number: 26882002
• Research Institution: Tohoku University
• Principal Investigator: 安西 眸 東北大学, 学際科学フロンティア研究所, 助教 (50736981)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: 血栓 / 脳動脈瘤 / in vitro試験

Outline of Annual Research Achievements

本研究は，特に脳動脈瘤近傍における血栓生成をターゲットとし，低レイノルズ数流れにおけるin vitro循環システムを開発し，実験および数値実験の比較から血流の定量的評価を行うことを目的とする．本年度はＮｉＴｉワイヤーに対する表面処理および，ワイヤー留置角度を変化した細胞実験を行った．これまでの研究より，内皮細胞の存在によって抗血栓性が上昇することが知られている．ワイヤー表面にコラーゲン加工を行った結果，ワイヤー表面の細胞被覆率が上がることが細胞実験より示された．またワイヤー留置角を変化させることでチャンバー内流れが変化することが数値流体解析より示された．チャンバー内流れの壁せん断応力分布に従って，内皮細胞密度が変化していることが示された．将来的には，このような不均一な内皮細胞分布および，血流分布による血栓化因子活性化を同時に考慮した研究が重要であると示唆された．

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Porosity Dependency of an Optimized Stent Design for Intracranial Aneurysm (2015)
  • Author(s): H. Anzai, Y. Yoshida, S. Sugiyama, H. Endo, Y. Matsumoto, M. Ohta
  • Journal Title: Technology and Health Care Volume: 23 Pages: 547-556
  • DOI: 0.3233/THC-151007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Parametric study of porous media as substitutes for flow-diverter stent (2015)
  • Author(s): Makoto Ohta, Hitomi Anzai, Yukihisa Miura and Toshio Nakayama
  • Journal Title: [Biomaterials and Biomedical Engineering Volume: 2 Pages: 111-125
  • DOI: 10.12989/bme.2015.2.2.111
  • Peer Reviewed
• [Presentation] Flow Simulations to Establish the Relationship between the Inflow Zone in the Neck of a Cerebral Aneurysm and the Positions of Struts (2016)
  • Author(s): K. Watanabe, H. Anzai, M. Ohta
  • Organizer: International Mechanical Engineering Congress & Exposition (IMECE2016)
  • Place of Presentation: Phoenix, USA
  • Year and Date: 2016-11-11 – 2016-11-17
  • Int'l Joint Research
• [Presentation] Computational fluid dynamics analysis of the bone marrow in cancellous bone as a non-Newtonian fluid (2016)
  • Author(s): M. Ohta, W. Sakuma, T. Nakayama, H. Anzai, M. Ito, K. Sado, S. Nakamura
  • Organizer: International Mechanical Engineering Congress & Exposition (IMECE2016)
  • Place of Presentation: Phoenix, USA
  • Year and Date: 2016-11-11 – 2016-11-17
  • Int'l Joint Research
• [Presentation] 低レイノルズ数領域における 血液環流フローチャンバーシステムの開発 (2016)
  • Author(s): 安西眸，白石泰之，山家智之，太田信
  • Organizer: 第39回日本バイオレオロジー学会年会
  • Place of Presentation: 東京
  • Year and Date: 2016-06-18 – 2016-06-19
• [Presentation] AVEC CFD 2016 (2016)
  • Author(s): 安西眸，Simon Tupin，渡邉 和浩，Sherif Rashad，太田信
  • Organizer: 第39回日本バイオレオロジー学会年会
  • Place of Presentation: 東京
  • Year and Date: 2016-06-18 – 2016-06-19
• [Presentation] Optimal interval of two strut wires relative to aneurysm inflow (2016)
  • Author(s): H. Anzai, K. Watanabe, M. Ohta
  • Organizer: European Congress on Computational Methods in Applied Sciences and Engineering (eccomas 2016)
  • Place of Presentation: Crete Island, Greece
  • Year and Date: 2016-06-05 – 2016-06-10
  • Int'l Joint Research / Invited
• [Presentation] Development of in-vitro and in-silico model for evaluating medical devices (2015)
  • Author(s): Makoto Ohta, Kaihong Yu, Ren Takahashi, Yuta Muramoto, Wataru Sakuma, Taihei Onishi, Hitomi Anzai
  • Organizer: Beijing-Tohoku Biomechanics Symposium
  • Place of Presentation: Beijing, China
  • Year and Date: 2015-11-25 – 2015-11-25
  • Int'l Joint Research
• [Presentation] Optimization of Flow Diverter design (2015)
  • Author(s): Makoto Ito, Mingzi Zhang, Hitomi Anzai, Makoto Ohta
  • Organizer: Beijing-Tohoku Biomechanics Symposium
  • Place of Presentation: Beijing, China
  • Year and Date: 2015-11-25 – 2015-11-25
  • Int'l Joint Research
• [Presentation] Co-relationship between Hemodynamics and Optimal Stent Structure (2015)
  • Author(s): Hitomi Anzai, Kazuhiro Watanabe, Yuuki Yoshida, Koji Shimoyama, Shigeru Obayashi, Makoto Ohta
  • Organizer: Proceedings of 2nd Biomedical Symposium and 1st Biomedical Engineering Symposium
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2015-11-16 – 2015-11-16
  • Int'l Joint Research
• [Presentation] Towards the Patient-specific Design of Intracranial Stents for Advanced Flow Diversion Efficacy (2015)
  • Author(s): Mingzi Zhang, Hitomi Anzai, Bastien Chopard, Makoto Ohta
  • Organizer: Proceedings of 2nd Biomedical Symposium and 1st Biomedical Engineering Symposium
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2015-11-16 – 2015-11-16
  • Int'l Joint Research
• [Presentation] In-Vitro Model and Cell Behaviors (2015)
  • Author(s): Makoto Ohta, Tomohito Watanabe, Xiaobo Han, Kaihong Yu, Taihei Onishi, Hitomi Anzai
  • Organizer: Proceedings of 2nd Biomedical Symposium and 1st Biomedical Engineering Symposium
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2015-11-16 – 2015-11-16
  • Int'l Joint Research
• [Presentation] Visualization of Flow Patterns through the Aneurysmal Orifice after Flow Diverter Optimizations with Different Objective Functions (2015)
  • Author(s): Zhang M, Anzai H, Ohta M
  • Organizer: [Interdisciplinary Cerebrovascular Symposium (Intracranial Stent Meeting 2015)
  • Place of Presentation: Gold Coast, Australia
  • Year and Date: 2015-11-13 – 2015-11-14
  • Int'l Joint Research
• [Presentation] Analysis of Relationship Between Stent Structure and Flow Stagnation Using Self-Organizing Maps for Realistic Aneurysm (2015)
  • Author(s): Anzai H, Yoshida Y, Shimoyama K, Obayashi S, Ohta M
  • Organizer: Interdisciplinary Cerebrovascular Symposium (Intracranial Stent Meeting 2015)
  • Place of Presentation: Gold Coast, Australia
  • Year and Date: 2015-11-13 – 2015-11-14
  • Int'l Joint Research / Invited
• [Presentation] Cell density distribution around the wire with flow condition (2015)
  • Author(s): Tomohito Watanabe, Han Xiaobo, Makoto Ohta,Hitomi Anzai, Hisatoshi Kobayashi
  • Organizer: [The Fifteenth International Symposium on Advanced Fluid Information
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2015-10-27 – 2015-10-29
  • Int'l Joint Research
• [Presentation] Development of a Program for Blood flow and Cell Behaviors Based on LBM Method (third report) (2015)
  • Author(s): Makoto Ohta, Mingzi, Zhang, Bastien Chopard, Xiaobo Han, Yujie Li, Hitomi Anzai
  • Organizer: AFI-TFI
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2015-10-27 – 2015-10-29
  • Int'l Joint Research
• [Presentation] CFD Alanyses for the flow in Cancellous Bone with LBM (2015)
  • Author(s): Wataru Sakuma, Toshio Nakayama, Hitomi Anzai, Shuji Nakamura, Katsuyuki Sado, Konstantin Kutscher, Martin Geier, Manfred Krafczyk, Makoto Ohta
  • Organizer: The 8th Asian-Pacific Conference on Biomechanics
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2015-09-16 – 2015-09-19
  • Int'l Joint Research
• [Presentation] Searching for valuable hemodynamic parameters for applying to optimization study (2015)
  • Author(s): Hitomi Anzai, Yuuki Yoshida, Mingzi Zhang, Makoto Ohta
  • Organizer: 9th European Solid Mechanics Conference,
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2015-07-06 – 2015-07-10
  • Int'l Joint Research / Invited
• [Presentation] Introduction of Optimization of Design using Combination of Lattice Boltzmann Method as CFD and Simulated Annealing for Reduction of Flow Speed (2015)
  • Author(s): Mingzi Zhang, Hitomi Anzai, Makoto Ohta
  • Organizer: 1st NUAA-Tohoku University Joint Symposium on Fluid Science
  • Place of Presentation: Nanjing, China
  • Year and Date: 2015-06-21 – 2015-06-22
  • Int'l Joint Research
• [Presentation] Manufacture-Oriented Design Optimization for a Flow Diverter Stent Using Lattice Boltzmann Method and Simulated Annealing (2015)
  • Author(s): Mingzi Zhang, Hitomi Anzai, Bastien Chopard, Makoto Ohta
  • Organizer: 11th World Congress of Structural and Multidisciplinary Optimization (WCSMO-11)
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2015-06-07 – 2015-06-12
  • Int'l Joint Research