Searching for a valid hemodynamic parameters for thrombus formation around intracranial stent

2015 Fiscal Year Final Research Report

• Project/Area Number: 26882002
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tohoku University
• Principal Investigator: Anzai Hitomi 東北大学, 学際科学フロンティア研究所, 助教 (50736981)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: 脳動脈瘤 / ステント / in vitro実験 / 内皮細胞 / 医療デバイス

Outline of Final Research Achievements

The aim of this study is to clarify the relationship between hemodynamic parameters and thrombus formation around medical implants. We developed in vitro system with cavity flow chamber for goat blood. This system can develop the flow environment under low Reynolds number <100 observed in human brain aneurysm. We also performed cell experiment with NiTi metallic wire. The results show inhomogeneous cell distribution depending on surface treatment of wire and wire structure.

Free Research Field

生体流動