2015 Fiscal Year Final Research Report
Transcription factor complex formation and gene expression control in energy metabolism
Project/Area Number |
26882008
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Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Applied health science
|
Research Institution | University of Tsukuba |
Principal Investigator |
HAN SONGIEE 筑波大学, 医学医療系, 研究員 (80729541)
|
Project Period (FY) |
2014-08-29 – 2016-03-31
|
Keywords | CREBH |
Outline of Final Research Achievements |
CREBH is a transcription factor, which is expressed in liver and intestine. CREBH regulates whole-body lipid metabolism. CREBH can bind to PPARα and its co-activator PGC-1α, leading to activation of FGF21 expression. CREBH also binds to SREBP, a master regulator for fatty acid and cholesterol synthesis. This association suppressed the transcriptional activity of SREBP. We identify that the cross-talk among CREB3L3 and transcription factors maintains energy homeostasis and improves metabolic syndrome. We developed liver-specific CREBH KO mice using one-step CRISSPR/Cas9 system. We find the deficiency of CREBH in liver leads to non-alcoholic fatty liver disease.
|
Free Research Field |
分子生物学
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