2015 Fiscal Year Final Research Report
Generation of inherited spinocerebellar ataxia model marmoset and assessment of drug treatment
| Project/Area Number |
26890005
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Keywords | 脳神経科学 / マーモセット / アデノ随伴ウイルスベクター / AAV / 脊髄小脳失調症 / 非ヒト霊長類 / ATXN / Ataxin |
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| Outline of Final Research Achievements |
The inherited spinocerebellar ataxia (SCA) model marmosets were generated and treated with a oral drug in this study. (1) I developed the method that SCA symptoms were stably emerged in marmosets using the adeno-associated virus (AAV) vector to inject the SCA causing gene into the marmoset cerebellum which is common degenerated tissue in SCA patients. (2) Because the cerebellum regulated motor behavior and motor learning, SCA patients have several movement disorders called cerebellar ataxia. I developed two behavior experiments to detect cerebellar ataxia of SCA model marmosets. (3) The SCA model marmoset was treated with a oral drug, but results of behavior experiments were not improved. Therefore the experimental design was changed and the experiment is continuing.
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| Free Research Field |
分子生物学
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