2015 Fiscal Year Final Research Report
Development and application of wide-field Ca2+ imaging of cerebral cortex.
| Project/Area Number |
26890026
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Nakashiba Toshiaki 国立研究開発法人理化学研究所, バイオリソースセンター, 研究員 (90733931)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Keywords | 脳神経 / イメージング / モデルマウス |
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| Outline of Final Research Achievements |
With the method of maternal immune activation, we have induced schizophrenia-like condition to mice expressing Ca2+ sensor, YC2.60, in either excitatory or inhibitory neurons of the cerebral cortex. Subsequently, we examined spontaneous neuronal activities and sensory stimulus-evoked responses through skulls under a macroscope. In addition, we have explored better condition to infect AAV virus for imaging at wider cortical area.
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| Free Research Field |
神経科学
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