Spatial and temporal regulation of membrane dynamics during cytokinesis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26891017
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Cell biology
• Research Institution: Okayama University
• Principal Investigator: Takeda Tetsuya 岡山大学, 医歯(薬)学総合研究科, 助教 (30302368)
• Research Collaborator: TAKEI Kohji 岡山大学, 大学院医歯薬学総合研究科, 教授 (40322226) ; Uchihashi Takayuki 金沢大学, 数物科学系, 教授 (30326300)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: 細胞質分裂 / F-BAR

Outline of Final Research Achievements

F-BAR domain protein Syndapin is essential for membrane dynamics during cytokinesis. Syndapin is phosphoregulated in cytokinesis but responsible kinases and phosphatases remained unclear. In this study, we identified PP1 phosphatases are required for Syndapin localisation to the cleavage furrow during cytokinesis. Furthermore, one of the essential mitotic kinases Plk1 directly phosphorylated Syndapin in vitro. These results suggested that Syndapin function during cytokinesis is spatially and temporally phosphoregulated by counter action of PP1 phosphatases and Polo-like kinase.

Free Research Field

細胞生物学